Prof. Yong X. Wang
Project Description and Objectives
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Pain is the most common reason for a physician consultation. It is a major symptom in many medical conditions and can significantly interfere with a person's general functioning and quality of life. Adequate treatment of pain, chronic pain in particular, remains a challenge for physicians and neurobiologists.
In this program, we aim to investigate the molecular mechanisms underlying chronic pain including neuropathic pain and cancer pain. In particular, identifying new target molecules and signal transduction pathways. We also aim to study antinociceptive effects of analgesic herbs (and their effective ingredients) and illustrate their mechanisms of action. The specific projects are involved in spinal microglial GLP-1 receptors and IL-10, astroglial D-amino acid oxidase and neuronal glycine receptors.
Lean biology of pain.
Set up chronic pain models of rodents and take behavior measurements; perform genetic, protein and other biochemical assays.
Test drugs including herb extracts and effective ingredients on animal models of chronic pain and illustrate their mechanisms of action.