Prof. Yongxiang Wang
Project Description and Objectives
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain is the most common reason for physician consultation. It is a major symptom in many medical conditions, and can significantly interfere with a person's general functioning and quality of life. Adequate treatment of pain, particularly chronic pain, remains a challenge for physicians and neurobiologists.
The objectives of the project are to investigate the molecular mechanisms underlying chronic pain including neuropathic pain and cancer pain, particularly identifying novel target molecules and signal transduction pathways. We also study antinociceptive effects of analgesic herbs (and their effective ingredients) and illustrate the mechanisms of action. The specific projects are involved in spinal microglial GLP-1 receptor, astroglial DAAO and neuronal glycine receptors.
Lean biology of chronic pain;
Set up chronic pain models of rodents and make behavior measurements
Perform gene, protein, and other biochemical assays
Test drugs including herb extracts on animal models of chronic pain and illustrate the mechanisms of action